I've just installed Komodo 4.1/4.2 on Ubuntu 'Gutsy' 7.10. When I click edit (in the main menu) - preferences, the preference dialog box appears but hangs.
This seems to be an issue with pre-release builds of Ubuntu Gutsy when using a GTK theme other than 'Human'. There seems to be a problem with 'inhuman' themes currently that prevents Komodo and Firefox from working correctly. Switching back to the 'Human' theme fixes the issue.
Only the Crux theme seems to exhibit this problem. Other default themes don't cause this. A fix is on the way for the 4.3 release.
http://bugs.activestate.com/show_bug.cgi?id=73850